منابع مشابه
Natural Knockouts: Natural Selection Knocked Out
In functional genomics studies, research is dedicated to unveiling the function of genes using gene-knockouts, model organisms in which a gene is artificially inactivated. The idea is that, by knocking out the gene, the provoked phenotype would inform us about the function of the gene. Still, the function of many genes cannot be elucidated, because disruption of conserved sequences, including p...
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Glucocorticoid receptors (GRs) are ligand-dependent transcription modulators. They belong to a superfamily of nuclear hormone receptors including receptors for steroid and thyroid hormones, retinoids, vitamin D and peroxisomal activators among others (1). The receptor can be divided into three functional domains: (1) an N-terminal activation domain (AF1 or t1); (2) a central DNA-binding domain;...
متن کاملWere you knocked out?--Yes, but I wasn't admitted.
A prospective study was undertaken of the effects of applying a more selective admission policy to a group of 6685 accident and emergency attenders with head injuries. The efficacy of such a policy was assessed by comparison with 5768 head injury attenders subject to an orthodox admission policy and collected retrospectively. Epidemiological characteristics of both study groups, of patients not...
متن کاملThe Knocked-out Unilateral Kidney! Causes and Presentation.
BACKGROUND Due to lack of awareness and non-availability of proper medical facilities in Pakistan, patients with kidney problems tend to seek urological consultation very late when their kidney has already knocked-out. The aim of the study was to find the various presenting complaints of patients having unilateral loss of kidney function and their aetiologies. The study also targeted the patien...
متن کاملNeurological and CT evaluation of knocked-out boxers.
Detailed neurological examinations, EEG and CT scans of the head were performed on 10 professional boxers aged 20 to 31 years shortly after being knocked-out. Intracerebral and subdural haematomas were not suspected or discovered. However, CT scans revealed cerebral atrophy in five of the boxers; this finding was most common in the boxers with the most bouts. The possible relationship of these ...
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ژورنال
عنوان ژورنال: British Dental Journal
سال: 2020
ISSN: 0007-0610,1476-5373
DOI: 10.1038/s41415-020-1721-5